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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Gynecol Oncol. 2021 Feb 2;161(1):113–121. doi: 10.1016/j.ygyno.2021.01.025

Figure 1: The majority ofTP53 mutations in GOG-86P dataset are in the DNA binding domain.

Figure 1:

The frequency of mutated codons was calculated as the number of variants at each nucleotide position relative to the total number of variants detected in the dataset. Mutations that occurred in ≥4 samples are annotated in the graph. R248: 14 variants; R273: 11 variants; R175: 6 variants; Y220: 4 variants; D281: 4 variants. TAD: transactivation domain; PRD: proline-rich domain; DBD: DNA binding domain; OD: tetramerization domain; CTD: C-terminal domain.