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. 2021 Mar 2;40(12):2309–2322. doi: 10.1038/s41388-021-01708-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Images of livers from NSG mice (n = 3) 5 weeks after injection of sorted HCT116 miR200b/c low or high cells, showing the metastatic colonies. B Bar graph showing the average metastatic colonies from (A) ±SD. C Oxygen Consumption Rate (OCR) measured by seahorse flux analyzer in HCT116 miR-200b/c low or high cells. D Bar graph showing basal respiration in HCT116 miR-200b/c low or high cells from (C). E Gene-set enrichment analysis of OXPHOS related genesets with the low and high categorized patient samples based on miR-200b/c sensor RNA-seq genes expression in the gene expression dataset GSE81980. GSEA was performed with the ranking of genes with signal2noise metric. F Scheme of the identified role of miR-200b/c as a molecular switch between EMT and proliferation. In B and D p values are from Student’s t test. Points are average ± SD. *<0.05, **<0.01, ***<0.001, ****<0.0001.