Table 2.

Effects of acutely administered sotalol on the brain concentrations of antiepileptic drugs in mice

Treatment (mg/kg)	Brain concentration (µg/ml)	Statistics
LTG (6.0) + vehicle	0.21 ± 0.03
LTG (6.0) + SOT (100.0)	0.16 ± 0.04**	t18 = 3.058, p = 0.0068
OXC (9.5) + vehicle	0.10 ± 0.02
OXC (9.5) + SOT (100.0)	0.17 ± 0.04***	t18 = 4.856, p = 0.0001
TPM (84.3) + vehicle	10.59 ± 0.36
TPM (84.3) + SOT (100.0)	11.57 ± 0.60***	t18 = 4.403, p = 0.0003
PGB (121.0) + vehicle	1.78 ± 0.31
PGB (121.0) + SOT (100.0)	1.70 ± 0.22	t18 = 0.6784, p = 0.5061

Results are presented as the means ± SD of at least eight determinations. Statistical analysis of the brain concentrations was performed using the unpaired Student’s t test. LTG lamotrigine, OXC oxcarbazepine, TPM topiramate, PGB pregabalin, SOT sotalol

**p < 0.001, ***p < 0.001 vs control (the respective antiepileptic drug + vehicle)