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. 2021 Mar 15;38(3):381–395. doi: 10.1007/s11095-021-02994-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Levofloxacin penetration indices (ratios of unbound area under the concentration-time profiles in plasma and target sites) for ISF (interstitial space fluid) over time for the dialysate-corrected mid-interval (“midpoint-CA”, light grey) and the dialysate-based integral compartmental analysis (“integral-CA”, dark grey). Median (solid lines) and 95% CI (shaded bands) from 1000 Monte-Carlo simulations are shown. Dots and whiskers show median, 2.5^th and 97.5^th percentiles of penetration indices calculated via non-compartmental analysis