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. 2021 Mar 15;38(3):381–395. doi: 10.1007/s11095-021-02994-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Probability of target attainment (PTA) versus minimum inhibitory concentration (MIC) of dosing regimens for the treatment of community-acquired pneumonia (CAP): 30-min 500 mg levofloxacin intravenous infusions once (q24h, a) and twice daily (q12h, b). PTA<90% (inadequacy of dosing regimen) is shaded in grey. Vertical lines represent MIC values including epidemiological cut-off values of the CAP-related pathogens Staphylococcus aureus (MIC = 0.5 mg/l) and Streptococcus pneumoniae (MIC = 2.0 mg/l). Differences in the evaluation of adequacy of dosing regimens between the dialysate-based integral compartmental analysis (integral-CA) and dialysate-corrected mid-interval compartmental analysis (midpoint-CA) at each MIC value are denoted as bold vertical lines. Inset plots show complete PTA profiles versus MIC. CLCR: creatinine clearance