Table II.

Parameter estimates from the noncompartmental analysis (NCA), the dialysate-corrected mid-interval compartmental analysis (midpoint-CA) and the dialysate-based integral compartmental analysis (integral-CA)

	NCA		Midpoint-CA	Integral-CA
Structural model	–		4 compartment mammillary	4 compartment mammillary
Structural PK parameters
Vtot [l]	104		82.7	81.1
CL [l/h]	8.26		7.35	7.78
Qtot [l/h]	–		115	97.6
Adipose tissue k13/k31	–		1.51	2.14
Muscle k14/k41	–		4.44	1.03
Impact influential patient characteristics
CL-CLCR [(ml/min)−1] a	0.90%1		1.26%2	1.12%2
CLsepsis b	−45.5%1		−52.8%2	−43.4%2
Qadi-albumin [(g/l)-1] c	–		8.19%2	7.25%2
Stochastic parameters
IIV (range)	–		46.5%CV-143%CV	26.4%CV-72.6%CV
RR related variability (adipose/muscle)	–		–	40.1%CV/50.3%CV
Residual variability	–		30.3%CV3	8.83%CV-28.3%CV4

¹Estimated via linear regression of CL versus CLCR centred on median and separate intercepts for sepsis patients and patients without sepsis. ²Estimated via linear/categorical parameter-covariate relationships. ³Single residual variability term for all biological matrices. ⁴Separate residual variability terms for all biological matrices. ^aChange of clearance per ml/min deviation of CLCR from 82.1 ml/min. ^bChange of clearance in patients with sepsis compared to patients without sepsis. ^cChange of Q_adi per g/l deviation of serum albumin concentration from 22.4 g/l.

CL: clearance, CLCR: creatinine clearance, CV: coefficient of variation, IIV: interindividual variability, k₁₃: transfer rate constant from central to adipose interstitial space fluid compartment, k₁₄: rate constant from central to muscle compartment, k₃₁: rate constant from adipose tissue compartment to central compartment, k₄₁: rate constant from muscle compartment to central compartment, Q_tot: sum of intercompartmental flows, Q_adi: intercompartmental flow between central compartment and adipose tissue compartment, V_tot: total volume of distribution, RR: relative recovery