Fig. 6.

MMP inhibitors enhance hypertrophic growth. Cardiomyocytes were incubated with the MMP inhibitors TAPI-0 (50 μM), TIMP2 (24 mM), and ARP-100 (50 nM) for 24 h. For detection of hypertrophic growth, incorporation of ¹⁴C-phenylalanine during 24 h, or cross-sectional area, was determined after 24 h. Data are expressed as percent increase relative to untreated controls and are means ± SE of 4–17 independent culture preparations. *Differences from unstimulated controls with p < 0.05