Table 2.
UAE associated SNPs reaching a genome-wide significance
| Chr | SNP | Position | Gene(s) | ref | alt | EA | EAF | BETA | SE | INFO | p value | AR2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 3 | rs143146694 | 6,263,450 | GRM7 | G | T | T | 0.035 | 37.81 | 5.667 | 0.931 | 2.69 × 10–11 | 0.034 |
| 3 | rs74971332 | 7,058,507 | GRM7 | C | G | G | 0.055 | 26.43 | 4.307 | 0.97 | 8.91 × 10–10 | 0.034 |
| 4 | rs75938525 | 56,659,946 | EXOC1/NMU | G | C | C | 0.048 | 31.06 | 5.029 | 0.956 | 6.93 × 10–10 | 0.034 |
| 6 | rs146871152 | 160,984,637 | LPA | C | T | T | 0.034 | 37.28 | 5.713 | 0.97 | 7.16 × 10–11 | 0.037 |
| 7 | rs146418897 | 22,440,870 | STEAP1B/RAPGEF5 | T | C | C | 0.033 | 36.85 | 5.743 | 0.941 | 1.49 × 10–10 | 0.034 |
| 7 | rs140221313 | 84,600,098 | SEMA3D | G | A | A | 0.038 | 31.17 | 5.534 | 0.934 | 1.84 × 10–8 | 0.034 |
| 7 | rs118160950 | 151,277,450 | PRKAG2 | C | T | T | 0.036 | 30.48 | 5.517 | 0.975 | 3.43 × 10–8 | 0.036 |
| 8 | rs141491217 | 94,068,096 | TRIQK | A | G | G | 0.039 | 33.01 | 5.84 | 0.932 | 1.63 × 10–8 | 0.035 |
| 13 | rs79163227 | 37,208,221 | SERTM1 | A | G | G | 0.056 | 25.92 | 4.664 | 0.941 | 2.84 × 10–8 | 0.035 |
| 13 | rs142317900 | 45,963,584 | TPT1-AS1 | G | A | A | 0.033 | 31.13 | 5.693 | 0.98 | 4.68 × 10–8 | 0.037 |
| 13 | rs151183316 | 46,021,543 | TPT1-AS1 | C | T | T | 0.035 | 30.6 | 5.54 | 0.981 | 3.43 × 10–8 | 0.035 |
| 14 | chr14:21617499_TCTCA_T | 21,617,499 | OR5AU1 | TCTCA | T | T | 0.052 | 28.48 | 5.126 | 0.871 | 2.87 × 10–8 | 0.034 |
| 14 | rs116622332 | 81,506,821 | TSHR | T | C | C | 0.046 | 30.67 | 4.897 | 0.98 | 3.99 × 10–10 | 0.036 |
| 14 | rs199612558 | 81,508,922 | TSHR | T | TA | TA | 0.046 | 29.57 | 4.835 | 0.983 | 1.00 × 10–9 | 0.037 |
| 14 | rs17111387 | 81,515,680 | TSHR | C | T | T | 0.068 | 22.24 | 4.025 | 0.996 | 3.42 × 10–8 | 0.037 |
| 15 | rs140272046 | 33,494,078 | FMN1/RYR3 | G | A | A | 0.042 | 33.38 | 5.886 | 0.886 | 1.47 × 10–8 | 0.034 |
| 17 | rs148283070 | 30,129,004 | COPRS | A | G | G | 0.034 | 34.15 | 5.922 | 0.972 | 8.42 × 10–9 | 0.036 |
| 22 | chr22:49949123_GA_G | 49,949,123 | BRD1 | GA | G | G | 0.052 | 27.83 | 4.805 | 0.945 | 7.22 × 10–9 | 0.034 |
Chr Chromosome, SNP single-nucleotide polymorphism, Position Chromosome position (GRCh37/hg19), Gene The name of Gene where the SNP is located, ref reference allele, alt alternative allele, EA effective allele, EAF effective allele frequency, BETA regression coefficient, SE Standard error of regression coefficient, INFO INFO score, AR2 Adjusted coefficient of determination. Bold type signifies that the SNPs were located on the gene. Normal type signifies that the SNPs were around the gene