Table 5.

Results from the biochemical assay after chronic (7x) 1MeTIQ treatment

Treatment	n	NA	NM	5-HT	5-HIAA
FCX
Control	5	265 ± 15	17 ± 3	253 ± 12	243 ± 8
MK-801	9	307 ± 22	26 ± 3	250 ± 18	241 ± 8
1MeTIQ-7x	5	368 ± 16***	53 ± 3***	358 ± 17***	187 ± 6***
1MeTIQ-7x + MK-801	6	354 ± 13**	42 ± 3***###	349 ± 15***###	196 ± 8***###
Effect of T1  Effect of T2  Interaction of T1 + T2		F(1/21) = 0.65 p = 0.43 F(1/21) = 18.44 p < 0.001 F(1/21) = 2.52 p = 0.13	F(1/22) = 0.21 p = 0.65 F(1/22) = 83.58 p < 0.001 F(1/22) = 11.17 p < 0.01	F(1/23) = 0.11 p = 0.75 F(1/23) = 38.21 p < 0.001 F(1/23) = 0.03 p = 0.85	F(1/22) = 0.22 p = 0.64 F(1/22) = 43.59 p < 0.001 F(1/22) = 0.58 p = 0.45
HIP
Control	6	301 ± 20	24 ± 3	226 ± 13	309 ± 12
MK-801	9	295 ± 16	25 ± 4	202 ± 18	327 ± 16
1MeTIQ-7x	6	356 ± 16*	44 ± 3**	337 ± 26**	273 ± 9
1MeTIQ-7x + MK-801	6	369 ± 18*#	41 ± 4**##	317 ± 21**##	299 ± 32
Effect of T1  Effect of T2  Interaction of T1 + T2		F(1/23) = 0.03 p = 0.85 F(1/23) = 12.13 p < 0.01 F(1/23) = 0.26 p = 0.62	F(1/22) = 0.08 p = 0.77 F(1/22) = 21.38 p < 0.001 F(1/22) = 0.36 p = 0.55	F(1/23) = 0.94 p = 0.34 F(1/23) = 25.25 p < 0.001 p < 0.01 p = 0.93	F(1/22) = 1.40 0.25p =  F(1/22) = 2.89 p < 0.10 F(1/22) = 0.04 p = 0.83

NA, 5-HT and their metabolites (NM. 5-HIAA) were measured in the Fcx and hippocampus using HPLC. The data were analyzed using two-way ANOVA and a post hoc Duncan’s MRT. The results are shown as the means ± SEM. N = 8–10 rats per group

*p < 0.05; **p < 0.01; ***p < 0.001 indicate significant changes compared to the control; ^#p < 0.05; ^##p < 0.01; ^###p < 0.001 indicate significant changes compared to the model (MK-801) group