Table 1.
Characteristics of study population.
| Variable | Tuberculosis group (T4) N = 9 | Control group (T4) N = 9 | |||
|---|---|---|---|---|---|
| n | % | n | % | ||
| Median age, IQR (years) | 45 (38–51) | - | 52 (41.5–56.5) | - | |
| Males | 7 | 77.8 | 7 | 77.8 | |
| Median body mass index, IQR (kg/m2) | 21.7 (20.5–23.2) | - | 25.8 (24.1–27.7) | - | |
| White ethnicity | 6 | 66.7 | 9 | 100 | |
| TB disease | Pulmonary | 4 | 44.4 | - | - |
| Extrapulmonary | 4 | 44.4 | - | - | |
| Pulmonary and extrapulmonary | 1 | 11.1 | - | - | |
| Median CD4 cell count at TB diagnosis, IQR (cells/μl) | 289 (152–422.5) | - | 456 (258.5–601) | - | |
| Median HIV-RNA at TB diagnosis, IQR (copies/ml) | 16 (0–121,500) | - | 0 (0–10,030) | - | |
| Median time between cell sampling at T4 and TB diagnosis, range (days) | 117 (29–312) | - | 0 (0–420) | - | |
| Median time between cell sampling at T3 and TB diagnosis, range (days) | 440 (68–846) | - | 392 (0–938) | - | |
| Antiretroviral therapy at TB diagnosis | 7 | 77.8 | 8 | 88.9 | |
| TST* | Negative | 5 | 55.6 | 2 | 22.2 |
| >5–9 mm | 0 | 0 | 0 | 0 | |
| 10–14 mm | 0 | 0 | 1 | 11.1 | |
| >15 mm | 1 | 11.1 | 0 | 0 | |
| Not done | 3 | 33.3 | 6 | 66.7 | |
| IGRA | Negative | 0 | 0 | 9 | 100 |
| Positive | 1 | 11.1 | 0 | 0 | |
| Indeterminate | 0 | 0 | 0 | 0 | |
| Not done | 8 | 88.8 | 0 | 0 | |
| TB diagnosis** | Culture positive | 3 | 33.3 | - | - |
| Sputum positive | 4 | 44.4 | - | - | |
| FNP PCR positive | 1 | 11.1 | - | - | |
| Lymphnode biopsy positive | 1 | 11.1 | - | - | |
*
TST, tuberculin skin test.
**
One TB patient had a positive IGRA with clinical suspicion of but had no microbiological confirmation.