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. 2021 Mar 12;12:582935. doi: 10.3389/fimmu.2021.582935

Table 1.

Demographic and clinical characteristics of arbovirus patients with neurological complications.

Demographic and clinical data Patients with neurological complications     Patients without neurological complications
(N/Total) % (N/Total) %
Age (years) 174/175 10/10
 Median 48.00 61.00
 Mean ± SD 46.20 ± 18.45 63.50 ± 4.34
Gender
 Male 80/175 45.71% 3/10 30.0%
 Female 95/175 54.29% 7/10 70.0%
Systemic manifestation
 Fever 132/175 75.42% 8/10 80.0%
 Rash 156/175 89.14% 3/10 30.0%
 Myalgia 113/175 64.57% 8/10 80.0%
 Arthralgia 131/175 74.80% 9/10 90.0%
Neurological signs and symptoms
 Headache 114/175 65.14%
 Altered consciousness 44/175 25.14%
 Limb weakness 123/175 70.28%
 Paraparesis 130/175 74.28%
 Quadriparesis 121/175 69.14%
Neurological manifestation
 Encephalitis Spectrum Disorder 43/175 24.57%
 Guillain-Barré Syndrome 46/175 26.29%
 Myelitis 24/175 13.71%
 Optic Neuritis 19/175 10.86%
 Other Syndromes 43/175 24.57%
Virological Diagnosis
 ZIKV+ 27/174 15.52% 0/10 0.0%
 DENV+ 5/174 2.87% 1/10 10.0%
 CHIKV+ 45/174 25.86% 0/10 0.0%
 CHIK+/ZIKV+ 41/174 23.56%
 CHIK+/DENV+ 5/174 2.87% 8/10 80.0%
 ZIKV+/DENV+ 3/174 1.72%
 CHIKV+/ZIKV+/DENV+ 9/174 5.17%
 Negative/Inconclusive 39/174 22.41% 1/10 10.0%

ZIKV+: positive test for Zika virus; DENV+: positive test for Dengue virus; CHIKV+: positive test for Chikungunya virus.