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. 2021 Mar 12;8:644376. doi: 10.3389/fmed.2021.644376

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Copyright © 2021 Li, Niu, Jing, Huang, Zhang, Chen, Shi, He, Zhang, Xiao, Zou, Yu and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of cirrhosis-related metabolome fingerprint. (A) Showed the decreasing trend of eigenmetabolite of metabolome fingerprint along with the progression of cirrhosis. (B) Demonstrated the cirrhosis-associated metabolic fingerprint (eigenmetabolite) revealed better capability to identify cirrhotic patients from non-cirrhotic ones(AUC:0.874). (C) The ROC curve of APRI in discriminating cirrhosis from non-cirrhotic AIH patients(AUC:0.763). (D) Showed that the increasing trend of eigenmetabolite of metabolome fingerprint from NC to CC and DC.