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. 2021 Mar 12;12:609629. doi: 10.3389/fimmu.2021.609629

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Copyright © 2021 Yabas, Orhan, Er, Tuzcu, Durmus, Ozercan, Sahin, Bhanuse, Morde, Padigaru and Sahin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Assessment of the knee swelling in rats with monosodium iodoacetate (MIA)-induced OA after NGUC supplementation. (A) Images of the hind knee joints 4 weeks after Next Generation Ultrasol Curcumin (NGUC) supplementation in rats with MIA-induced OA. Graphs demonstrate (B) left knee joint diameter, (C) right knee joint diameter and (D) the ratio of right to left diameter values in rats with MIA-induced OA. The data are presented as means ± SD (n=7 for each group). Statistical differences among the groups were determined by one-way ANOVA followed by a post-hoc Tukey test; ^** p < 0.01, ^*** p < 0.001, ^**** p < 0.0001. NGUC, next generation ultrasol curcumin; OA, osteoarthritis; OA+Cur 1, 100 mg/kg of NGUC; OA+Cur 2, 200 mg/kg of NGUC.