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. 2021 Mar 12;12:609629. doi: 10.3389/fimmu.2021.609629

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Copyright © 2021 Yabas, Orhan, Er, Tuzcu, Durmus, Ozercan, Sahin, Bhanuse, Morde, Padigaru and Sahin

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Next Generation Ultrasol Curcumin (NGUC) supplementation on protein expressions of pro-inflammatory mediators in rats with monosodium iodoacetate (MIA)-induced OA. (A) Representative protein expressions of IL-1β, IL-6 and TNF-α levels in synovial tissue of rats. β-actin was referenced to ensure equal protein loading. Graphs demonstrate densitometric analysis of the western blots for (B) IL-1β, (C) IL-6 and (D) TNF-α. Data represent percent of the control values. Blots were repeated at least three times. Statistical differences among the groups were determined by one-way ANOVA followed by a post-hoc Tukey test; ^*** p < 0.001, ^**** p < 0.0001. NGUC, next generation ultrasol curcumin; OA, osteoarthritis; OA+Cur 1, 100 mg/kg of NGUC; OA+Cur 2, 200 mg/kg of NGUC; IL, interleukin; TNF-α, tumor necrosis factor alpha.