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. 2021 Mar 23;4(6):e202000903. doi: 10.26508/lsa.202000903

Figure 6. pmCiC is expressed in the stroma of human cancerous tissues.

Figure 6.

(A, B) immunohistochemical staining of pmCIC showed strong expression in human pancreatic (A) and gastric cancer glands (B) (DAB—150 μm). (C, D) In close contact to infiltrating cancer glands, there is also a prominent expression in micro-vessels (v) but also in spindle cells (→) of the tumour microenvironment (TME) in both cancer types (C, D) (DAB, — 50 μm). The latter cell type of the TME could be identified by vimentin as tumour associated fibroblasts (data not shown). (E) Consecutive examination of lymph node metastasis (E) (DAB—50 μm) demonstrate a positive tumour gland but also expression in micro-vessels (v) and fibroblasts. (F) The same was true for a metastatic gastric cancer shown in figure (F) (DAB, — 50 μm). (G) A table showing the number/percentage of human tumour tissues expressing pmCiC in cancer cells and in cancer-associated stroma cells.