Table 2.

Top variants in loci associated with CAA formation with p < 5 × 10⁻⁶.

SNV	Chr	Positiona	Gene region	Allele		Alt. allele frequencies
				Ref	Alt	CAA (+)	CAA (−)	OR (95% CI)	p
rs6017006	20	41934620	Intergenic	G	A	0.13	0.04	5.0 (2.8–9.0)	2.3 × 10−8
rs7871579	9	139990530	MAN1B1 intron	T	C	0.26	0.15	2.8 (1.8–4.2)	4.6 × 10−7
rs2449565	5	169135662	DOCK2 intron	A	G	0.75	0.61	2.3 (1.6–3.3)	1.9 × 10−6
rs10762437	10	73058469	UNC5B intron	A	G	0.25	0.16	2.5 (1.7–3.8)	3.5 × 10−6
rs35932034	3	106262305	Intergenic	T	C	0.03	0.11	0.2 (0.09–0.4)	3.7 × 10−6
rs1989051	8	129294118	Intergenic	T	C	0.69	0.57	2.2 (1.6–3.1)	4.0 × 10−6

ORs were calculated using a Wald test, and p values were calculated using a Score test. All effects are relative to the alternate allele, ref/alt alleles are defined by the HRC reference panel.

Chr. chromosome, CAA coronary artery aneurysm, OR odds ratio.

^aGRCh37/hg19 position.