Fig. 4. Additive value of ctDNA to FTV-based predictors of pCR at T1.

a Area under the curve (AUC) for prediction of pCR early during NAC (T1: 3 weeks after initiation treatment) for FTV alone and FTV + ctDNA treated as a continuous variable. b Positive predictive value (PPV), negative predictive value (NPV) and accuracy for prediction of pCR of FTV alone and FTV + ctDNA treated as a dichotomous variable.