FIG. 4.

GM-CSF treatment improves levels of key mitochondrial proteins in alveolar macrophages from HIV Tg rats. Alveolar macrophages from HIV Tg rats and their littermate controls were cultured with or without GM-CSF before being stained for Grp75 and VDAC. HIV transgene expression reduced VDAC but did not alter Grp75 levels. GM-CSF treatment resulted in significantly higher levels of both proteins in HIV Tg macrophages but did not significantly change wild-type macrophage levels. Data presented as MFI ± SEM, n = 4 animals and 100–150 cells/group. *p < .05 versus HIV. Grp75, glucose-regulated protein 75; MFI, mean fluorescence intensity; VDAC, voltage-dependent anion channel.