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. 2020 Sep 16;36(2):131–142. doi: 10.1007/s12291-020-00923-4

Fig. 2.

Fig. 2

Enrichment of CTCs. Approaches for CTC enrichment either exploit the difference between CTCs and blood cells in their the biological (marker dependent) or physical properties(marker independent). Marker-dependent methods include positive (using antibodies against tumour-associated or tissue-specific antigens) and negative selection (using antibodies against blood cell-specific antigens). Marker independent approach utilizes the differences in physical properties like size, charge etc