Fig. 2.
Enrichment of CTCs. Approaches for CTC enrichment either exploit the difference between CTCs and blood cells in their the biological (marker dependent) or physical properties(marker independent). Marker-dependent methods include positive (using antibodies against tumour-associated or tissue-specific antigens) and negative selection (using antibodies against blood cell-specific antigens). Marker independent approach utilizes the differences in physical properties like size, charge etc