Table 3.
Comparison of oxidative stress biomarkers between healthy controls, mildly active SLE, and moderate to highly active SLE
| Oxidative stress biomarker | Group 1 Healthy controls N = 80 | Group 2 Low disease activity (SLEDAI ≤ 5) N = 27 | Group 3 Moderate–High disease activity (SLEDAI ≥ 6) N = 53 | Statistical significance p value |
|---|---|---|---|---|
| OxLDL (ng/L) |
2605.68 (135–32,345) |
2494.76 (671–28,752) |
2586.55 (503–28,650) |
0.726 |
| MDA (μM) |
0.50 (0–4) |
1.73 (1–2) |
2.91 (1–8) |
< 0.001 |
| 8-OHdG (ng/mL) |
17.28 (0–151) |
18.53 (0–304) |
20.12 (0–725) |
< 0.05 |
| Total antioxidant status (TAS) (units/mL) |
23.77 (0–234) |
17.44 (0–20) |
12.02 (0–16) |
< 0.001 |
| MDA/TAS ratio |
0.015 (0.0–1.13) |
0.10 (0.05–1.90) |
0.30 (0.08–7.89) |
< 0.001 |
Statistical test used was Kruskal–Wallis Test, Values are median (IQR)
SLEDAI systemic lupus erythematosus disease activity index, OxLDL Oxidised LDL, MDA Malondialdehyde, 8-OHdG 8-hydroxy-2′-deoxyguanosine, TAS total antioxidant status