TABLE 1.

Beneficial effects of combinations of pharmacological targets.

Target combination	sEH/PPARγ	DPP4/MCH-1R	DPP4/GPR119	DPP4/ACE
Positive implications for MetS	Antidiabetic, cardioprotective, renoprotective, blood pressure-lowering	Antidiabetic, weight loss	Antidiabetic, glucose homeostasis	Antidiabetic, treating hyperglycemia and hypertension
Target combination	sEH/FXR	FXR/PPARα	FXR/PPARγ	PPARγ/AT1	PPARγ/GK
Positive implications for MetS	Anti-inflammatory, anti-steatotic	Suppressing lipogenesis	Antifibrotic, liver protective	Antihypertensive, antidiabetic	Improves insulin resistance, reducing blood glucose levels