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Activation of cyclic AMP pathway through various genetic defects in adrenocortical tumors and hyperplasias. GNAS, gene coding for the stimulatory subunit α of the G-protein (Gsα); PDE8B, phosphodiesterase 8B gene; PDE11A, phosphodiesterase 11A gene; PRKACA, protein kinase, cAMP-dependent, catalytic, alpha; PRKAR1A, protein kinase, cAMP-dependent, regulatory, type I, α gene.
