Figure 4.

Effect of ionomycin and oridonin on eryptosis hallmarks of naïve (A) and P. falciparum-infected erythrocytes (B). Significant increase of PS exposure and significant decrease of cell size were observed in naïve and infected erythrocytes exposed to 1 µM of ionomycin (4 h in incomplete RPMI). However, no significant increase in these eryptosis hallmarks was observed in naïve and P. falciparum-infected erythrocytes exposed up to 10 µM of oridonin. Data presented corresponds to five independent experiments performed in triplicate (N=5). Individual data points represent the means of the three technical replicates for each experiment. The bars represent the mean and SD of the five independent experiments.