Figure 5.

Growth-inhibition curves of P. falciparum exposed to seven eryptosis inducers. In vitro asynchronous cultures of P. falciparum were cultured in cRPMI with a range of concentrations of compounds (up to 50 µM) for 72 h. DNA content was measured as a proxy for parasite growth, and normalized with the positive inhibition control (cultures exposed to chloroquine and artemisinin) and with the negative inhibition control (cultures exposed to DMSO). IC₅₀ concentrations are indicated for each compound in µM. Data presented corresponds to five independent experiments performed in triplicate (N=5). Each IC₅₀ curve is represented as the mean and SD of the five independent experiments.