Table 2.

Eryptosis hallmarks of naïve and P. falciparum-infected erythrocytes exposed to seven eryptosis inducers and growth inhibition (IC₅₀) on P. falciparum.

Compound	Eryptosis hallmarks		P. falciparum IC50 (μM)
	Naïve erythrocytes	P. falciparum – infected erythrocytes
Ionomycin	↑ PS exposure ↓ Cell Size (1 μM)	↑ PS exposure ↓ Cell Size (1 μM)	3.32
Benzethonium	Ns	Ns *	0.49
Oridonin	Ns	Ns	2.00
Amiodarone	↑ Calcium (5 μM)	Ns	2.10
BAY 43-9006	Ns	Ns	7.48
Cordycepin	Ns	Ns	12.07
Apigenin	Ns	Ns	65.78

Eryptosis hallmarks include PS exposure, cell size, intracellular calcium levels and hemolysis data (see Figure 4 and Supplementary Figures 1– 5 for detailed data on each compound). Ionomycin was used as a positive control. Significant changes (↑ = increase or ↓ = decrease) are indicated with the concentration at which the effect is observed. *: infected erythrocytes incubated with 5 μM benzethonium present an increase in hemolysis levels, which has not been observed at 10 μM.