Fig. 4. Histomorphological changes in the prostate. (A) Representative prostate tissue samples of each group were selected and stained with H&E. Shown are microscopy images of prostate samples obtained at ×200 magnification. (B) Epithelial thickness values are expressed as mean±standard error of the mean (n=6). ^ap<0.001 compared to the control group. ^bp<0.001 compared to the benign prostate hyperplasia (BPH) group. Statistical analyses were performed by ANOVA and Dunnett's multiple comparison test. CO: costunolide, DCL: dehydrocostus lactone.