Table 3. Liver and spleen weights.

Variable	Control	Testosterone treatment
		BPH	CO (0.075 mg/kg)	DCL (0.075 mg/kg)	Finasteride (0.8 mg/kg)
Liver weight (g)	11.28±0.87	9.57±0.49a	10.72±1.71	9.38±0.73	9.46±0.79
Spleen weight (g)	0.72±0.10	0.62±0.04	0.62±0.14	0.67±0.09	0.70±0.12

Values are presented as mean±standard error of the mean (n=6). A rat model of benign prostate hyperplasia (BPH) was induced with daily injections of 5 mg/kg testosterone for 16 weeks after castration. Then, 0.075 mg/kg costunolide (CO), 0.075 mg/kg dehydrocostus lactone (DCL), or 0.8 mg/kg finasteride was administered orally to the rats for 8 weeks after induction.

^ap<0.05 compared to the control group. Statistical analyses were conducted using ANOVA and Dunnett's multiple comparison test.