Table 2.

Effects of concussion on integrated local efficiency (IE_loc) and integrated global efficiency (IE_glob), for concussed athletes at acute injury (ACU), return to play (RTP) and one year post-RTP (1YR). This includes cross-sectional differences relative to controls (CTL) and within-subject longitudinal changes between imaging sessions. Tables report mean effects with bootstrapped 95% confidence intervals (95% CIs), bootstrap ratios (BSRs) and p-values. Significant effects at an FDR threshold of 0.05 are noted with ‘*’.

		IEloc				IEglob
		Mean	95%CI	BSR	p	Mean	95%CI	BSR	p
Cross-sectional	ACU-CTL	0.015	[− 0.090, 0.119]	0.28	0.739	0.190	[0.008, 0.352]	2.14	0.032
	RTP-CTL	− 0.060	[− 0.182, 0.071]	− 0.93	0.351	0.042	[− 0.170, 0.234]	0.41	0.657
	1YR-CTL	− 0.003	[− 0.137, 0.129]	− 0.04	0.932	− 0.091	[− 0.287, 0.113]	− 0.87	0.342
Longitudinal	RTP-ACU	− 0.075	[− 0.166, 0.020]	− 1.57	0.129	− 0.147	[− 0.295, − 0.004]	− 2.01	0.039*
	1YR-ACU	− 0.018	[− 0.164, 0.121]	− 0.26	0.790	− 0.281	[− 0.514, − 0.057]	− 2.41	0.011*
	1YR-RTP	0.057	[− 0.0714, 0.182]	0.88	0.346	− 0.133	[− 0.360, 0.088]	− 1.17	0.237
CS1 regression	ACU	0.037	[− 0.474, 0.674]	0.13	0.888	0.873	[− 0.017, 1.948]	1.76	0.044
	RTP	0.287	[− 0.377, 1.063]	0.81	0.384	0.657	[− 0.476, 1.874]	1.11	0.237
	1YR	− 0.484	[− 1.144, 0.255]	− 1.36	0.197	− 0.299	[− 1.331, 0.907]	− 0.53	0.572
CS2 regression	ACU	− 0.121	[− 1.271, 1.151]	− 0.20	0.851	− 0.405	[− 2.074, 1.605]	− 0.43	0.657
	RTP	− 0.522	[− 1.520, 0.846]	− 0.87	0.399	− 0.081	[− 2.481, 2.127]	− 0.07	0.934
	1YR	− 0.586	[− 2.079, 1.071]	− 0.73	0.519	− 2.844	[− 5.052, − 0.738]	− 2.59	0.004*