Figure 3.

Longitudinal causal interference analysis: anti-AQP4-IgG-Titer does not correlate with disease activity or progression. The level of anti-AQP4-IgG antibody titers remain unchanged after increased number of attacks (A,B). Also, the number of relapses per year (ARR) do not correlate with the anti-AQP4-IgG status (C). The level of anti-AQP4-IgG titers are not increased if more symptom areas are affected (D). A dichotomy can be seen if the level of anti-AQP4-IgG is plotted vs. the anti-MOG-IgG titer (E): NMOSD patients which are anti-MOG-IgG positive do not have anti-AQP4-IgG and vice versa. AU, arbitrary unit.