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. 2021 Mar 12;12:601298. doi: 10.3389/fimmu.2021.601298

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Copyright © 2021 Nguyen, Nguyen, Zhao, Schank, Dang, Cao, Khanal, Chand Thakuri, Lu, Zhang, Li, Morrison, Wu, El Gazzar, Ning, Wang, Moorman and Yao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GAS5 controls CD4 T cell response and apoptosis beyond miR-21-mediated signaling pathways. (A) Relative expressions of GAS5 (n = 5) and miR-21 (n = 4) in CD4 T cells from PLHIV, following overexpression of GAS5, determined by RT-qPCR. (B) Left panel, sequences of GAS5-mutant and GAS5-WT constructs, and the corresponding miR-21 binding site. Right panel, relative miR-21 expression in CD4 T cells from PLHIV transfected with control, GAS5-WT, or GAS5-mutant constructs (n = 6). (C–E) Expression of T cell activation, apoptosis, and exhaustion markers in CD4 T cells from PLHIV transfected with control, GAS5-WT, or GAS5-mutant construct, determined by flow cytometry (n = 10).