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. 2021 Mar 12;12:639491. doi: 10.3389/fimmu.2021.639491

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Copyright © 2021 Berke, Sun, Ong, Sanati, Huffman, Brunson, Loney, Ostrow, Racz, Zhao, Xiang, Masci, Zheng, Wu and He.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Reactome pathway enrichment analysis highlighting Interferon alpha/beta Signaling pathways found to be significant in both (A) Gaucher et al. (15) and (B) Scherer et al. (14). The pathway diagram is in the Systems Biology Graphical Notation (SBGN) (47) format. Results from both studies imply the stimulation of expression of IFN-induced genes though the Gaucher et al. (15) study shows more hit genes than the Scherer et al. study. Intriguingly, the Gaucher et al. (15) study implies STAT1, which is not shown in the Scherer et al. (14) study, while the Scherer study has USP18 that is not shared in the Gaucher et al. (15) study.