Table 1.
Top 10 vaximmutors defined by number of associated vaccines.
| Category | Vaximmutor | Host species | Associated vaccines | NCBI gene ID | Description |
|---|---|---|---|---|---|
| Antibodies | IgG | Mouse | 37 (all up) | 16059 | Antibody |
| IgG2a | Mouse | 18 (all up) | 668478 | Antibody | |
| IgG1 | Mouse | 15 (all up) | 16017 | Antibody | |
| Th1 cytokines | IFN-gamma | Mouse | 47 (all up) | 15978 | Pro-inflammatory Th1 response |
| IL-2 | Mouse | 8 (all up) | 16183 | Th1, T cell stimulation | |
| Th2 cytokines | IL-4 | Mouse | 12 (8 up, 4 down) | 16189 | Th2, IgE production |
| More innate immune response factors | IL-6 | Mouse | 8 (all up) | 16193 | Th1/Th2 differentiation |
| TNFα | Mouse | 11 (7 up, 4 down) | 21926 | Pro-inflammatory Th1 response | |
| CASP-1 | Human | 5 (all up) | 834 | Pro-inflammatory, pyroptosis | |
| TLR8 | Human | 5 (4 up, 1 up and down at different days) | 51311 | Adjuvant effect, NF-KB pathway activation, PAMP recognition |