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. 2021 Mar 25;12:1876. doi: 10.1038/s41467-021-22166-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a mTORC1 activity is increased in SARS-CoV-2 infected Vero kidney epithelial cells. Protein was extracted from Vero cells infected with SARS-CoV-2 for 24 h and immunoblotted for the indicated proteins (representative of two biological independent samples). b mTORC1 activity is increased in ALI mucociliary cultures derived from two different donors. Protein was extracted from ALI cultures infected with SARS-CoV-2 for 72 h and immunoblotted for the indicated proteins (n = 2 biological independent samples). c pAKT and pERK are increased in SARS-CoV-2 infected NHBE ALI cultures (representative of two biological independent samples). d mTORC1 activity is increased in COVID-19 patient lungs. IHC staining of p4EBP1 and the macrophage marker CD68 on lungs from COVID-19 and non-COVID-19 patients. Images are representative of two out of five COVID-19 patient lungs and nine out of nine non-COVID-19 lungs. Red arrows indicate cells positive for p4EBP1. Scale bar 50 µM.