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. 2021 Mar 25;12:1891. doi: 10.1038/s41467-021-22132-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–d Tissues of positive control rhesus D6-Ctrl. MARV IHC positive (brown) a sinusoidal lining cells of the liver and Kupffer cells, b mononuclear cells in the splenic red and white pulp, c MARV IHC positive (red) epithelial and mononuclear cells within the ciliary body of the eye (arrows), d MARV IHC positive (brown) of mononuclear cells within the sinuses of the axillary lymph node. e–h Tissues of remdesivir treated rhesus D6-GS-1 that succumbed to disease 14 dpi. e No appreciable MARV IHC immunolabeling of the liver, f No appreciable MARV IHC immunolabeling of the spleen, g MARV IHC positive (red) epithelial and mononuclear cells within the ciliary body of the eye (arrows), d MARV IHC positive (brown) of glial cells within brain. i–l Tissues of remdesivir treated rhesus D6-GS-3 that succumbed to disease 7 dpi. MARV IHC positive (brown) i sinusoidal lining cells of the liver and Kupffer cells, j mononuclear cells in the splenic red and white pulp, k MARV IHC positive (red) mononuclear cells within the ciliary body of the eye (arrow), l MARV IHC positive (brown) of mononuclear cells within the sinuses of the axillary lymph node. m–p Tissues of MR186-YTE treated rhesus D6-MR-1 that succumbed to disease 9 dpi. MARV IHC positive (brown) m sinusoidal lining cells of the liver and Kupffer cells, n mononuclear cells in the splenic red and white pulp, o MARV IHC positive (red) epithelial and mononuclear cells within the ciliary body of the eye (arrows), p MARV IHC positive (brown) of mononuclear cells within the sinuses of the axillary lymph node. q–t Tissues of combination remdesivir and MR186-YTE treated rhesus D6-Comb-1 that succumbed to disease 14 dpi. q No appreciable MARV IHC immunolabeling of the liver, r No appreciable MARV IHC immunolabeling of the spleen, s No appreciable MARV IHC immunolabeling (red) of the eye, t MARV IHC positive (brown) of glial cells within brain (arrow). u–x Tissues of combination remdesivir and MR186-YTE treated rhesus D6-Comb-2 that survived to study end point. u No appreciable MARV IHC immunolabeling of the liver, v No appreciable MARV IHC immunolabeling of the spleen, w No appreciable MARV IHC immunolabeling (red) of the eye, x No appreciable MARV IHC immunolabeling of the brain. y–bb Tissues of combination remdesivir and/ MR186-YTE treated rhesus D6-Comb-4 that succumbed to disease 7 dpi. MARV IHC positive (brown) y sinusoidal lining cells of the liver and Kupffer cells, z mononuclear cells in the splenic red and white pulp, aa MARV IHC positive (red) epithelial and mononuclear cells within the ciliary body of the eye (arrows), bb MARV IHC positive (brown) of mononuclear cells within the sinuses of the axillary lymph node. Images captured at 20x (a, e, i, m, q, u, y, d, h, l, p, t, x, & bb) 10x (b, f, j, n, r, v, z, c, g, k, o, s, w, & aa) IHC labeling for anti-MARV antigen (brown) (a, b, d, e, f, h, i, j, l, m, n, p, q, r, t, u, v, x, y, z, & bb) IHC labeling for anti-MARV antigen (red) (c, g, k, o, s, w, & aa). For each animal, displayed images are representative of histopathological lesions and immunoreactivity observed in multiple tissue slices and/or fields of view, unless otherwise indicated.