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. 2021 Mar 25;11:6838. doi: 10.1038/s41598-021-85331-1

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Inhibition of ERK 1/2 activity prevents the induction of matrix metalloproteinases, collagen type 3 and interleukin 11 gene expression in tendon explants. (A) Gene expression of murine Mmps after 12 days ex vivo culture. Data are normalized to 2 reference genes, N = 8. (B) Gene expression of human MMPs after 3-days ex vivo culture. Data are normalized to 2 reference genes, N = 3. (C) Gene expression of Col1a1, Col3a1 and Il11 in murine tissue after 12 days ex vivo culture. Data are normalized to 2 reference genes, N = 8. (D) Detection of IL11 protein levels in supernatants obtained from cultured tendon fascicles by ELISA, N = 4. Friedman test with Dunn’s multiple comparison test. Gene expression data is plotted on a logarithmic scale. GraphPad Prism (version 8.4.3) was used to perform statistical analyses and generate the figures. Box plots (25th and 75th percentiles) with whiskers (5th and 95th percentiles), median (line) and mean (+). Bar plots represent mean values + SD. All statistical tests unless otherwise stated: Repeated measures ANOVA with Tukey's multiple comparisons test with *p < 0.05, **p < 0.01, ***p < 0.001.