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. 2021 Mar 25;11:6850. doi: 10.1038/s41598-021-86267-2

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© The Author(s) 2021, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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OPLS-DA coefficient loadings plot of different metabolites that were altered in the pairwise comparison (predose, T₀ vs postdose, T_1h). Resonances pointing upwards reflect metabolites that were greater in the pre-dose group relative to the post-dose group, whereas resonances pointing downwards indicate lower concentrations of metabolites in the pre-dose group relative to the post-dose group.