Table 3.
Univariate analysis of prognostic factors for lung cancer patients by age groups.
| ≤ 45 | > 45 | Total | ||||
|---|---|---|---|---|---|---|
| Characteristic | median survival month (95%CI) | P value | median survival month (95%CI) | P value | median survival month (95%CI) | P value |
| Overall | 23.0 (20.678,25.322) | 27.0 (24.858,29.124) | 26.0 (24.343,27.657) | 0.001 | ||
| Sex | ||||||
| Male | 21.0 (17.616,24.384) | 24.0 (21.679,26.321) | 23.0 (21.215,24.785) | |||
| Female | 25.0 (21.106,28.894) | 0.002 | 38.0 (32.419,43.581) | < 0.001 | 32.0 (27.937,36.063) | < 0.001 |
| Family history | ||||||
| Yes | 20.0 (19.709,23.291) | 28.0 (25.620,30.380) | 25.0 (21.674,28.326) | |||
| No | 25.0 (22.123,27.877) | 0.012 | 31.0 (20.612,41.388) | 0.408 | 26.0 (24.674,27.867) | 0.284 |
| Smoking | ||||||
| Yes | 19.0 (15.699,22.301) | 24.0 (21.685,26.315) | 23.0 (21.262,24.738) | |||
| No | 25.0 (21.507,28.493) | 0.001 | 35.0 (30.038,39.692) | < 0.001 | 30.0 (26.724,33.276) | < 0.001 |
| Drinking | ||||||
| Yes | 21.0 (16.014,25.986) | 26.0 (22.970,29.030) | 24.0 (21.469,26.531) | |||
| No | 25.0 (22.158,27.842 | 0.427 | 30.0 (26.424,33.576) | 0.007 | 27.0 (24.826,29.174) | 0.012 |
| BMI | ||||||
| < 24.0 | 23.0 (20.508,25.492) | 26.0 (23.066,28.934) | 25.0 (23.017,26.983) | |||
| > 24.0 | 25.0 (20.931,29.069) | 0.357 | 29.0 (25.952,32.048) | 0.043 | 29.0 (26.198,31.802) | 0.027 |
| Symptoms at diagnosis | ||||||
| Yes | 22.0 (19.686,24.314) | 26.0 (23.945,28.055) | 24.0 (22.599,25.401) | |||
| No | 39.0 (17.972,60.028) | < 0.001 | 52.0 (41.754,62.246) | < 0.001 | 45.0 (38.106,51.894) | < 0.001 |
| Site | ||||||
| Left | 23.0 (18.733,27.267) | 25.0 (22.571,27.429) | 24.0 (22.013,25.987) | |||
| Right | 25.0 (21.735,28.265) | 0.443 | 31.0 (27.006,34.994) | 0.004 | 28.0 (25.496,30.504) | 0.007 |
| Subside | ||||||
| upper lobe | 33.0 (25.807,40.193) | 43.0 (35.924,50.076) | 41.0 (31.265,40.735) | |||
| Middle lobe | 15.0 (4.024,25.976) | 58.0 (44.756,71.244) | 42.0 (22.468,37.532) | |||
| Low lobe | 37.0 (24.367,49.633) | 0.174 | 44.0 (35.745,52.255) | 0.504 | 42.0 (35.683,52.317) | 0.773 |
| Cancer stage at diagnosis | ||||||
| I + II | 63.0 (40.487,85.513) | – | 79.0 (67.849,90.151) | |||
| III + IV | 18.0 (215.569,20.341) | < 0.001 | 19.0 (17.529,20.471) | < 0.001 | 18.0 (16.769,19.231) | < 0.001 |
| Pathology | ||||||
| SCLC | 18.0 (12.791,23.209) | 16.0 (13.669,18.331) | 19.0 (16.391,21.609) | |||
| NSCLC | 25.0 (22.218,27.782) | 0.034 | 31.0 (28.398,33.602) | < 0.001 | 27.0 (25.030,28.970) | < 0.001 |
| CEA | ||||||
| Normal | 29.0 (23.543,34.457) | 27.0 (23.208.30.792) | 28.0 (24.507,31.493) | |||
| Abmormal | 19.0 (16.680,21.320) | < 0.001 | 21.0 (18.709.23.231) | < 0.001 | 20.0 (18.406,21.549) | < 0.001 |
| SCC | ||||||
| Normal | 24.0 (20.467,27.533) | 31.0 (27.388,34.612) | 28.0 (25.076,30.924) | |||
| Abmormal | 18.0 (8.368,27.632) | 0.006 | 20.0 (12.242,27.758) | 0.001 | 20.0 (15.424,24.576) | < 0.001 |
| NSE | ||||||
| Normal | 31.0 (23.192,38.808) | 28.0 (24.052,31.948) | 29.0 (25.321,32.679) | |||
| Abmormal | 17.0 (13.805,20.195) | < 0.001 | 20.0 (16.390,23.610) | < 0.001 | 19.0 (16.707,21.293) | < 0.001 |
| EGFR | ||||||
| Mutant | 24.0 (8.882,39.118) | 39.0 (16.171,61.829) | 34.0 (26.573,41.427) | |||
| Not mutant | 29.0 (21.958,36.042) | 0.051 | 40.0 (30.651,49.349) | 0.306 | 34.0 (20.139,47.861) | 0.111 |
| Surgery | ||||||
| Yes | 60.0 (41.879,78.121) | 69.0 (63.190,74.810) | 69.0 (61.807,76.193) | |||
| No | 18.0 (15.483,28.157) | < 0.001 | 18.0 (16.606,19.394) | < 0.001 | 18.0 (16.812,19.188) | < 0.001 |
| Radiotherapy | ||||||
| Yes | 23.0 (18.494,27.506) | 33.0 (29.594,36.406) | 30.0 (27.607,32.393) | |||
| No | 24.0 (21.343,26.657) | 0.213 | 20.0 (18.147,21.863) | < 0.001 | 21.0 (19.170,22.830) | < 0.001 |
| Chemotherapy | ||||||
| Yes | 23.0 (20.444,25.556) | 31.0 (24.720,37.280) | 29.0 (24.600,33.400) | |||
| No | 23.0 (19.368,28.632) | 0.497 | 27.0 (24.482,29.518) | 0.222 | 26.0 (24.111,27.899) | 0.094 |
| Targeted therapy | ||||||
| Yes | 24.0 (21.301,26.699) | 28.0 (25.551,30.449) | 27.0 (25.151,28.849) | |||
| No | 21.0 (19.025,22.975) | 0.474 | 26.0 (21.219,30.781) | 0.436 | 23.0 (19.909,26.091) | 0.207 |