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. 2021 Mar 25;12(4):317. doi: 10.1038/s41419-021-03580-4

Fig. 4. FBXO6 regulates ovarian cancer cells proliferation, migration, and invasion.

Fig. 4

A The cell growth curve of OVCAR-3 cells transfected with scramble or FBXO6 shRNAs. B Clonogenic assay of OVCAR-3 cells transfected with scramble or FBXO6 shRNAs. C The cell growth curve of FBXO6+/+ and FBXO6−/− A2780 cells. D Clonogenic assay of FBXO6+/+ and FBXO6−/− A2780 cells. E Representative images of migrated FBXO6+/+ and FBXO6−/− A2780 cells in a transwell assay with Matrigel. F Quantification of migrated cells in E. Data were shown as mean ± SD of three independent experiments. **p < 0.01. G The migration of FBXO6+/+ and FBXO6−/− A2780 cells in scratch experiments. Data were shown as mean ± SD of three independent experiments. **p < 0.01. H FBXO6+/+ (1 × 107) and FBXO6−/− A2780 cells were subcutaneously injected into each nude mouse for about 4 weeks. Tumor volumes were detected at the indicated dates. n = 6 for each group. ***p < 0.001. I The image shows the representative tumor-bearing mice and xenografts for each group. J At the end of 4 weeks, mice were killed and the tumor weights were measured. **p < 0.01.