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. 2021 Mar 12;11:579323. doi: 10.3389/fcimb.2021.579323

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Copyright © 2021 Li, Pi and Li

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pathways of SCFA affecting bone homeostasis. 1) SCFA reduces intestinal pH and increases calcium absorption. 2) SCFA inhibits the differentiation of osteoclasts by increasing the occurrence of intracellular glycolysis. 3) SCFA inhibits the activity of HDAC, thus increasing the differentiation of Treg cells. 4) SCFA can induce the increase of IGF-I.