Figure 5.

Delayed onset and reduced tumor growth by 4T1-PIP cells is abrogated in immunodeficient mice. PIP expressing 4T1 tumors (PIP) and empty vector controls (EV) were injected into Rag2^−/−γc^−/− double knockout (DKO) BALB/c mice and onset of palpable tumor (latency) was determined (A). The tumor growth was measured with digital calipers (B). At sacrifice, the tumors were excised, and the weight was determined (C). A representative photo image of the excised tumors is shown (D). Results are representative of two different experiments. Results are expressed as mean ± SEM of n = 4 mice/group, T-test and two-way ANOVA were conducted.