Table 1.
List of the 10 single nucleotide polymorphism considered in the genetic risk score computation.
Reported gene | SNP | Functional class | Alleles | MAF (%) Mexicans | MAF (%) 1000 GP (37) | OR | 95% CI | p | Reference |
---|---|---|---|---|---|---|---|---|---|
SLC16A11 | rs13342232 | synonymous | A/G | 41.6 | 16.3 | 1.9 | 1.2-3.0 | 0.003 | (26) |
ADORA1 | rs903361 | intergenic | A/G | 27.8 | 37.7 | 1.9 | 1.2-3.0 | 0.010 | (27) |
CADM2 | rs13078807 | intron | A/G | 9.3 | 8.7 | 2.2 | 1.2-4.0 | 0.009 | (27) |
GNPDA2 | rs10938397 | intergenic | A/G | 32.5 | 32.6 | 2.2 | 1.4-3.7 | 9.0E-4 | (27) |
VEGFA | rs6905288 | downstream | G/A | 35.5 | 35.5 | 1.4 | 1.1-2.1 | 0.044 | (27) |
FTO | rs9939609 | intron | T/A | 20.6 | 34.0 | 1.8 | 1.0-2.3 | 0.039 | (27) |
POC5 | rs2112347 | upstream | G/T | 29.6 | 48.9 | 1.7 | 1.4-2.1 | 6.9E-4 | (23) |
RPS10 | rs206936 | intron | A/G | 34.6 | 35.5 | 1.5 | 1.2-1.8 | 0.005 | (23) |
GLIS3 | rs7034200 | intron | A/C | 35.5 | 44.4 | 2.1 | 1.8-2.4 | 1.9E-6 | (23) |
LINGO | rs10968576 | intron | A/G | 21.2 | 20.4 | 2.0 | 1.6-2.4 | 4.3E-4 | (23) |
SNP, single nucleotide polymorphism; MAF, minor allele frequency; 1000 GP, 1000 genome project; OR, odds ratio; CI, confidence interval.