Figure 1.

Photomicrographs showing a few scattered APP/Aβ- (A) and the absence of Aβ₄₂-ir (D) plaques in the ML of the cerebellar cortex of a 66-year-old female HC (A,D) compared to numerous APP/Aβ- (B,C) and Aβ₄₂-ir (E,F) plaques in a 46-year-old male with DSD+ (B,E) and a 98-year-old female with AD (C,F) case, respectively. High-power photomicrographs of Aβ₄₂-ir filament-like bundles within diffuse plaques in a 98-year-old female with AD (G) and 47-year-old female with DSD– (H), and Aβ₄₂-ir blood vessels (arrows) in a 46-year-old male with DSD+ (I). (A–C) were counterstained with Gill's hematoxylin to aid in the visualization of cerebellar laminae. HC, healthy control; DS, Down syndrome; AD, Alzheimer's disease; ML, molecular layer; GL, granular cell layer. Scale bars: (E) = 100 μm applies to (A,B,D); F = 100 μm applies to (C); G,H = 10 μm; (I) = 50 μm.