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. 2021 Mar 12;13:645334. doi: 10.3389/fnagi.2021.645334

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Copyright © 2021 Miguel, Perez, Malek-Ahmadi and Mufson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Boxplots showing a significant reduction in the number of p75^NTR positive PCs in both DS (A; Kruskal–Wallis, p = 0.03) and AD (A; Kruskal–Wallis, p = 0.001) compared to HC. Adjusting for age and gender revealed statistically similar results when DSD– cases were removed from the analysis (D; ANCOVA, p < 0.011). Optical density (OD) measurements of p75^NTR-ir PC soma revealed significantly higher values in HC compared to AD (B; Kruskal–Wallis, p = 0.009) but not different from subjects with DS. Similar statistical findings were found when adjusted for age and gender (E; ANCOVA, p < 0.011). Boxplots revealed a significant reduction in the number of TrkA-ir PCs in AD compared to HC but not in DS (C; Kruskal–Wallis, p < 0.05) even after adjusting for age and gender (F; ANCOVA, p < 0.001). * denotes significance between groups.