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. 2021 Mar 12;13:645334. doi: 10.3389/fnagi.2021.645334

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Copyright © 2021 Miguel, Perez, Malek-Ahmadi and Mufson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary diagram depicts cellular alterations in DS and AD compared to HC cases. Note the reduction of Parv containing PCs as well as Parv (basket/stellate) and Calr (Golgi, Lugaro, and brush) positive interneurons in the cerebellar cortex of an adult with DS. By contrast, TrkA and p75^NTR-ir PC numbers were lower in AD compared to HC, but not in DS. CF, climbing fibers; MF, mossy fibers; PF, parallel fibers. Used with permission from Barrow Neurological Institute, Phoenix, Arizona.