Skip to main content
. 2021 Mar 12;13:645334. doi: 10.3389/fnagi.2021.645334

Figure 3.

Figure 3

Low-power photomicrographs of cresyl violet staining of the cerebellar cortex showing the ML, PC layer, and GL in 63-year-old male HC (A), 46-year-old male with DSD+ (B), and 79-year-old female with AD (C) cases. Insets in the upper left corners show high-power images of PC perikaryon outlined in the black boxes in (A–C). Note the absence of the PC dendritic arbor (A–C). Photomicrographs of SMI-32-ir non-phosphorylated high-molecular-weight neurofilaments in PC dendritic arbors and axons in a female 69-year-old HC (D), male 46-year-old DSD+ (E) and a male 85-year-old AD (F) case. Insets in (D–F) show high-power images of boxed SMI-32-ir PCs and proximal dendrites. (G–I) Swollen SMI-32-ir proximal PC axons or torpedoes (arrows) in the GL of a male 51-year-old HC (G), 60-year-old female with DS (H) and 98-year-old female with AD (I) case. Scale bars: (C) = 50 μm applies to (A,B,D–F); inset in (C) = 15 μm, insets in (A,B,D–F) = 10 μm; (G–I) = 25 μm.