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. 2021 Mar 12;13:645334. doi: 10.3389/fnagi.2021.645334

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Copyright © 2021 Miguel, Perez, Malek-Ahmadi and Mufson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Box plots showing no differences in the number of Calb-ir PCs (A) even when adjusted for age and gender (D) between the groups. By contrast, HCs had a significantly greater number of Parv-ir PCs compared to subjects with AD (B; Kruskal–Wallis, p = 0.001). When adjusted for age and gender, HCs had significantly more Parv positive PCs than both subjects with DS and AD (E; ANCOVA, p < 0.001), while Parv-ir interneurons showed significantly lower numbers in DS compared to HC and AD cases (C; Kruskal–Wallis, p < 0.001) even after adjusting for age and gender (F; ANCOVA, p < 0.001). * denotes significance between groups.