Figure 1.

ITZ and EB interacted with S2 domain of spike protein via virtual screening. a) Potential drug binding sites of S protein in pre‐fusion conformation, b) ITZ colored in magenta and EB colored in green were bound to the pre‐fusion conformation of S protein from virtual screening, c) binding details of ITZ and EB to pre‐fusion of S protein. d) Potential drug binding sites of S protein in post‐fusion conformation, e) ITZ colored in magenta and EB colored in green bound to the post‐fusion conformation of S protein from virtual screening, f) binding details and binding affinities of ITZ and EB to post‐fusion of S protein, g) binding between ITZ and SARS‐CoV‐2 S protein by BLI, h) binding between EB and SARS‐CoV‐2 S protein by BLI.