TABLE 1.
Relative search volume (RSV) of dermatologic symptoms, conditions, treatments and procedures
| March 15‐May 9 | May 10‐July 4 | July 5‐October 31 | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2020 | 2016‐2019 | % Change | P value | 2020 | 2016‐2019 | % Change | P value | 2020 | 2016–2019 | % Change | P value | |
| Blistering | 44.38 ± 2.02 | 46.91 ± 1.81 | −5.39 | .352 | 74.63 ± 3.22 | 65.72 ± 2.21 | 13.56 | .023 | 55.88 ± 3.19 | 57.93 ± 1.98 | −3.54 | .585 |
| Bruising | 51 ± 1.98 | 70.09 ± 1.18 | −27.24 | <.001 | 75.38 ± 3.06 | 84 ± 1.48 | −10.26 | .011 | 76.06 ± 2.20 | 76.47 ± 1.12 | −0.54 | .867 |
| Callus | 51.0 ± 4.36 | 43.47 ± 0.96 | 17.32 | .092 | 57.25 ± 1.38 | 48.13 ± 0.95 | 18.95 | <.001 | 49.82 ± 1.22 | 46.04 ± 1.12 | 8.21 | .022 |
| Comedones | 59.63 ± 3.82 | 53.38 ± 2.31 | 11.71 | .162 | 73.25 ± 2.07 | 57.34 ± 2.52 | 27.75 | <.001 | 75.53 ± 3.03 | 52.88 ± 1.70 | 42.83 | <.001 |
| Skin swelling | 60.88 ± 2.85 | 64.25 ± 2.43 | −5.25 | .367 | 72.38 ± 5.74 | 60.88 ± 2.37 | 18.89 | .064 | 71.59 ± 1.94 | 62.13 ± 1.69 | 15.23 | <.001 |
| Dandruff | 86 ± 3.94 | 72.63 ± 1.54 | 18.41 | .002 | 76.5 ± 2.26 | 61.78 ± 0.90 | 23.83 | <.001 | 70.82 ± 1.26 | 62.79 ± 0.84 | 12.79 | <.001 |
| Dry skin | 57.13 ± 2.13 | 52 ± 1.28 | 9.87 | .039 | 53 ± 1.50 | 44.69 ± 0.69 | 18.59 | <.001 | 48.82 ± 0.75 | 44.51 ± 0.67 | 9.68 | <.001 |
| Erythema | 62.38 ± 1.77 | 77.97 ± 1.31 | −19.99 | <.001 | 67 ± 3.17 | 79.41 ± 1.20 | −15.63 | <.001 | 74.82 ± 1.2 | 79.5 ± 0.92 | −5.89 | .002 |
| Hair loss | 71.25 ± 3.29 | 70.28 ± 0.73 | 1.38 | .774 | 85.25 ± 1.31 | 74.22 ± 0.90 | 14.86 | <.001 | 92.06 ± 1.04 | 79.82 ± 0.51 | 15.33 | <.001 |
| Hair shedding | 71.75 ± 5.89 | 48.78 ± 1.39 | 47.09 | <.001 | 79.38 ± 2.17 | 55.06 ± 1.58 | 44.17 | <.001 | 75.18 ± 1.28 | 59.63 ± 1.06 | 26.08 | <.001 |
| Hives | 80.88 ± 0.98 | 83.56 ± 0.95 | −3.21 | .048 | 87.75 ± 1.99 | 90.34 ± 1.14 | −2.87 | .258 | 84.82 ± 2.08 | 86.31 ± 0.87 | −1.73 | .509 |
| Sweating | 61.63 ± 0.79 | 58.75 ± 1.01 | 4.90 | .024 | 72.38 ± 2.87 | 72.84 ± 2.06 | −0.63 | .894 | 73 ± 2.73 | 72.29 ± 1.53 | 0.98 | .821 |
| Hyperpigmentation | 75.63 ± 4.91 | 54.75 ± 1.99 | 38.14 | <.001 | 93.25 ± 1.46 | 56.47 ± 1.72 | 65.13 | <.001 | 79.53 ± 2.59 | 52.01 ± 1.33 | 52.91 | <.001 |
| Hypopigmentation | 28.13 ± 3.87 | 37.44 ± 1.97 | −24.87 | .032 | 43.75 ± 3.45 | 42.16 ± 2.47 | 3.77 | .707 | 46.71 ± 2.07 | 46.51 ± 1.59 | 0.43 | .941 |
| Skin irritation | 58.63 ± 3.601 | 59.25 ± 1.1 | −1.05 | .868 | 72.25 ± 2.50 | 61.47 ± 1.47 | 17.54 | <.001 | 65.76 ± 1.71 | 60.88 ± 1.20 | 8.02 | .02 |
| Itch | 63.5 ± 1.58 | 59.03 ± 0.72 | 7.57 | .01 | 82.13 ± 2.72 | 77.25 ± 1.82 | 6.32 | .136 | 77.53 ± 2.56 | 73.49 ± 1.31 | 5.50 | .159 |
| Skin mole | 57.5 ± 3.03 | 65.28 ± 1.34 | −11.92 | .019 | 83.5 ± 2.39 | 79.69 ± 1.74 | 4.78 | .197 | 71.29 ± 1.96 | 67.43 ± 1.29 | 5.72 | .099 |
| Nail discoloration | 37 ± 6.03 | 34.75 ± 2.25 | 6.47 | .726 | 40.75 ± 4.19 | 35.61 ± 3.13 | 14.43 | .326 | 41.35 ± 4.66 | 38.63 ± 2.18 | 7.04 | .596 |
| Nail thickening | 38.86 ± 9.29 | 29.04 ± 4.04 | 33.82 | .333 | 22.75 ± 2.41 | 31.88 ± 2.84 | −28.64 | .014 | 28.5 ± 2.60 | 26.91 ± 1.38 | 5.91 | .589 |
| Nevi | 42.88 ± 3.90 | 61.63 ± 2.38 | −30.42 | <.001 | 53.88 ± 3.85 | 63.81 ± 2.40 | −15.56 | .029 | 59.82 ± 2.10 | 64.46 ± 1.36 | −7.20 | .064 |
| Nevus | 50.63 ± 4.20 | 78.09 ± 1.52 | −35.16 | <.001 | 66.13 ± 2.64 | 77.44 ± 1.49 | −14.60 | <.001 | 74.35 ± 1.70 | 76.94 ± 1.10 | −3.37 | .2 |
| Oily skin | 67.5 ± 2.63 | 71.66 ± 1.06 | −5.81 | .143 | 83.75 ± 3.56 | 76.16 ± 1.50 | 9.97 | .049 | 77.71 ± 1.42 | 76.32 ± 1.16 | 1.82 | .45 |
| Oily hair | 78.13 ± 2.92 | 64.56 ± 1.16 | 21.02 | <.001 | 78.38 ± 1.93 | 58.97 ± 1.01 | 32.92 | <.001 | 79.53 ± 2.23 | 64.12 ± 1.03 | 24.03 | <.001 |
| Onycholysis | 46.38 ± 4.52 | 47 ± 2.51 | −1.32 | .904 | 59.5 ± 4.22 | 43.28 ± 2.28 | 37.48 | .001 | 45.24 ± 3.70 | 49.07 ± 1.94 | −7.81 | .358 |
| Pruritus | 54 ± 1.81 | 61.31 ± 1.39 | −11.92 | .001 | 56.88 ± 1.56 | 57.28 ± 1.57 | −0.70 | .854 | 63.47 ± 1.37 | 64.59 ± 1.56 | −1.73 | .591 |
| Purple skin | 78.38 ± 3.62 | 62.53 ± 1.70 | 25.35 | <.001 | 90.63 ± 1.31 | 71.66 ± 2.48 | 26.47 | <.001 | 75.59 ± 2.12 | 63.41 ± 1.32 | 19.21 | <.001 |
| Rash | 63.75 ± 2.41 | 64.47 ± 0.82 | −1.12 | .778 | 83.25 ± 1.18 | 81.88 ± 1.56 | 1.67 | .482 | 68.82 ± 2.88 | 71.62 ± 1.31 | −3.91 | .377 |
| Redness | 73.38 ± 1.81 | 82.94 ± 1.36 | −11.53 | <.001 | 78.25 ± 1.23 | 79.84 ± 1.10 | −1.99 | .336 | 72.71 ± 1.14 | 75.1 ± 0.80 | −3.18 | .085 |
| Skin scaling | 33.88 ± 3.18 | 39.66 ± 3.13 | −14.57 | .195 | 39.63 ± 4.83 | 36.69 ± 3.20 | 8.01 | .612 | 38.35 ± 3.45 | 41.51 ± 2.23 | −7.61 | .442 |
| Skin discoloration | 65.38 ± 3.55 | 64.25 ± 1.76 | 1.76 | .777 | 80 ± 2.84 | 74.34 ± 1.80 | 7.61 | .092 | 69.12 ± 1.63 | 66.9 ± 1.68 | 3.32 | .342 |
| Skin ulcer | 57.25 ± 2.99 | 47.44 ± 2.73 | 20.68 | .015 | 64.75 ± 3.18 | 48.13 ± 2.64 | 34.53 | <.001 | 57.82 ± 2.43 | 53.87 ± 1.80 | 7.33 | .190 |
| Mouth ulcer | 78.5 ± 2.81 | 70.44 ± 1.87 | 11.44 | .017 | 76.63 ± 2.37 | 73.66 ± 1.74 | 4.03 | .313 | 77.18 ± 2.22 | 72.99 ± 1.16 | 5.74 | .094 |
| Wheal | 28.0 ± 1.49 | 30.91 ± 1.29 | −9.41 | .14 | 31.88 ± 2.21 | 30.22 ± 1.40 | 5.49 | .527 | 31.06 ± 2.43 | 34.82 ± 1.41 | −10.80 | .179 |
| Wound | 77.38 ± 1.05 | 78.72 ± 1.05 | −1.70 | .364 | 87.50 ± 2.05 | 82.44 ± 1.4 | 6.14 | .041 | 93.47 ± 0.89 | 83.71 ± 0.91 | 11.66 | <.001 |
| Acne | 86.5 ± 3.22 | 87.44 ± 0.86 | −1.08 | .778 | 94.88 ± 1.40 | 86.5 ± 0.79 | 9.69 | <.001 | 91.82 ± 0.93 | 86.76 ± 0.68 | 5.83 | <.001 |
| Actinic keratosis | 47.88 ± 2.88 | 64.91 ± 2.04 | −26.24 | <.001 | 62.63 ± 2.75 | 69.0 ± 2.13 | −9.23 | .067 | 64.29 ± 1.81 | 64.84 ± 1.41 | −0.85 | .812 |
| Angioedema | 35.13 ± 1.67 | 46.44 ± 1.05 | −24.35 | <.001 | 38.88 ± 1.32 | 46.84 ± 1.09 | −16.99 | <.001 | 41.82 ± 1.20 | 50.38 ± 1.13 | −16.99 | <.001 |
| Apthous stomatitis | 32.0 ± 0.0 | 47.43 ± 5.23 | −32.53 | .003 | 33.0 ± 0.47 | 43.2 ± 0.51 | −23.61 | <.001 | 46.67 ± 9.54 | 46.93 ± 3.38 | −0.55 | .980 |
| Atopic dermatitis | 49.63 ± 7.29 | 32.28 ± 1.71 | 53.75 | .020 | 42.0 ± 1.43 | 33.19 ± 1.85 | 26.54 | <.001 | 39.18 ± 0.96 | 33.38 ± 1.17 | 17.38 | <.001 |
| Basal cell carcinoma | 50.38 ± 2.22 | 77.19 ± 1.61 | −34.73 | <.001 | 65.13 ± 2.23 | 77.56 ± 1.87 | −16.03 | <.001 | 75.71 ± 1.86 | 80.13 ± 1.14 | −5.52 | .042 |
| Skin candida | 23.88 ± 3.32 | 38.28 ± 2.75 | −37.62 | .001 | 26.75 ± 2.41 | 35.0 ± 1.49 | −23.57 | .004 | 26.59 ± 1.68 | 32.87 ± 1.14 | −19.11 | .002 |
| Chickenpox | 47.38 ± 2.21 | 40.59 ± 3.17 | 16.73 | .079 | 38.88 ± 1.92 | 37.47 ± 1.43 | 3.76 | .557 | 44.18 ± 1.21 | 38.62 ± 0.95 | 14.40 | <.001 |
| Contact dermatitis | 71.5 ± 1.75 | 64.78 ± 1.64 | 10.37 | .005 | 78.13 ± 1.66 | 70.97 ± 1.72 | 10.09 | .003 | 72.35 ± 1.70 | 70.44 ± 1.36 | 2.71 | .381 |
| Cosmetic allergy | 25.5 ± 0.35 | 43.81 ± 4.60 | −41.79 | <.001 | 46.0 ± 4.95 | 43.0 ± 4.70 | 6.98 | .660 | 46.83 ± 8.21 | 36.33 ± 1.18 | 28.90 | .205 |
| Demodex | 21.88 ± 1.53 | 25.53 ± 0.75 | −14.30 | .031 | 22.5 ± 0.83 | 30.31 ± 2.15 | −25.77 | .001 | 23.12 ± 0.87 | 25.96 ± 0.38 | −10.94 | .003 |
| Dermatitis | 83.63 ± 3.46 | 77.59 ± 1.68 | 7.78 | .116 | 90.88 ± 0.65 | 80.53 ± 1.79 | 12.85 | <.001 | 86.12 ± 0.84 | 81.38 ± 1.29 | 5.82 | .002 |
| Diaper dermatitis | 32.75 ± 4.93 | 44.16 ± 3.07 | −25.84 | .050 | 34.88 ± 3.62 | 34.86 ± 2.82 | 0.06 | .998 | 38.24 ± 3.58 | 40.33 ± 2.53 | −5.18 | .633 |
| Drug allergy | 40.5 ± 2.59 | 44.31 ± 1.94 | −8.60 | .239 | 33.63 ± 1.49 | 40.13 ± 2.13 | −16.20 | .012 | 39.0 ± 2.57 | 36.54 ± 1.10 | 6.73 | .379 |
| Drug eruption | 31.88 ± 6.31 | 40.23 ± 2.97 | −20.76 | .231 | 33.25 ± 3.38 | 40.9 ± 3.24 | −18.70 | .102 | 35.41 ± 3.36 | 39.49 ± 2.18 | −10.33 | .309 |
| Erythema multiforme | 37.63 ± 3.28 | 55.94 ± 2.23 | −32.73 | <.001 | 42.0 ± 2.09 | 51.72 ± 2.05 | −18.79 | .001 | 43.76 ± 1.79 | 54.93 ± 1.44 | −20.33 | <.001 |
| Eczema | 79.0 ± 2.63 | 80.06 ± 1.71 | −1.32 | .735 | 84.38 ± 1.37 | 79.0 ± 1.68 | 6.81 | .013 | 73.94 ± 0.89 | 72.63 ± 1.08 | 1.80 | .351 |
| Fungal skin infection | 46.25 ± 3.26 | 49.88 ± 1.90 | −7.28 | .337 | 57.88 ± 3.21 | 61.28 ± 2.44 | −5.55 | .398 | 56.24 ± 1.63 | 60.44 ± 1.78 | −6.95 | .081 |
| Hand eczema | 71.75 ± 4.25 | 46.5 ± 2.11 | 54.30 | <.001 | 67.38 ± 4.20 | 49.88 ± 2.01 | 35.08 | <.001 | 58.0 ± 2.60 | 47.37 ± 1.56 | 22.44 | <.001 |
| Herpes zoster | 63.25 ± 2.55 | 70.59 ± 1.70 | −10.40 | .016 | 66.38 ± 2.54 | 69.19 ± 1.69 | −4.06 | .356 | 70.47 ± 1.81 | 71.71 ± 0.97 | −1.73 | .547 |
| Hyperhidrosis | 11.63 ± 0.75 | 14.38 ± 0.56 | −19.12 | .003 | 17.38 ± 0.75 | 19.03 ± 1.81 | −8.67 | .398 | 21.06 ± 4.82 | 17.85 ± 0.84 | 17.98 | .512 |
| Ichthyosis | 17.25 ± 1.28 | 20.66 ± 1.21 | −16.51 | .054 | 14.0 ± 0.90 | 24.09 ± 2.90 | −41.88 | .001 | 16.06 ± 1.08 | 18.04 ± 0.78 | −10.98 | .136 |
| Melanoma | 41.63 ± 1.62 | 65.03 ± 1.79 | −35.98 | <.001 | 55.13 ± 1.47 | 68.06 ± 0.86 | −19.0 | <.001 | 54.71 ± 0.76 | 62.59 ± 0.76 | −12.59 | <.001 |
| Melasma | 47.75 ± 4.45 | 41.72 ± 1.27 | 14.45 | .193 | 83.13 ± 4.70 | 55.47 ± 1.78 | 49.86 | <.001 | 70.18 ± 3.61 | 49.03 ± 1.54 | 43.14 | <.001 |
| Miliaria | 47.75 ± 7.51 | 39.91 ± 2.40 | 19.64 | .320 | 58.5 ± 2.86 | 58.44 ± 3.08 | 0.10 | .988 | 46.24 ± 4.10 | 50.84 ± 2.43 | −9.05 | .334 |
| Milium | 26.13 ± 2.19 | 25.97 ± 2.31 | 0.62 | .960 | 32.38 ± 1.02 | 30.16 ± 2.33 | 7.36 | .383 | 24.24 ± 2.10 | 33.18 ± 1.98 | −26.94 | .002 |
| Molluscum | 62.0 ± 2.33 | 77.38 ± 1.32 | −19.88 | <.001 | 81.0 ± 2.41 | 84.91 ± 1.34 | −4.60 | .157 | 71.53 ± 1.77 | 77.6 ± 1.21 | −7.82 | .005 |
| Mycosis fungoides | 18.63 ± 1.72 | 19.44 ± 1.04 | −4.17 | .687 | 19.75 ± 2.11 | 20.19 ± 0.88 | −2.18 | .848 | 19.94 ± 1.13 | 20.26 ± 0.74 | −1.58 | .811 |
| Pediculosis | 46.63 ± 4.30 | 56.09 ± 2.41 | −16.87 | .055 | 46.75 ± 4.87 | 43.97 ± 2.33 | 6.32 | .607 | 51.71 ± 4.04 | 50.13 ± 2.26 | 3.15 | .734 |
| Pemphigoid | 6.25 ± 0.42 | 9.47 ± 0.34 | −34.0 | <.001 | 9.38 ± 0.43 | 10.13 ± 0.50 | −7.40 | .254 | 10.53 ± 0.40 | 10.56 ± 0.31 | −0.28 | .954 |
| Pemphigus | 44.5 ± 3.61 | 48.22 ± 1.48 | −7.71 | .340 | 43.13 ± 1.97 | 50.34 ± 1.51 | −14.32 | .004 | 49.12 ± 1.65 | 53.31 ± 1.49 | −7.86 | .059 |
| Pityriasis rosea | 54.5 ± 2.28 | 77.5 ± 1.74 | −29.68 | <.001 | 66.75 ± 1.86 | 73.28 ± 1.98 | −8.91 | .016 | 56.29 ± 1.49 | 67.43 ± 1.15 | −16.52 | <.001 |
| Psoriasis | 71.0 ± 1.21 | 75.56 ± 1.48 | −6.03 | .017 | 75.0 ± 0.88 | 74.22 ± 1.37 | 1.05 | .632 | 71.0 ± 1.08 | 71.5 ± 0.75 | −0.70 | .704 |
| Rosacea | 72.0 ± 2.91 | 82.13 ± 1.49 | −12.33 | .002 | 72.75 ± 1.68 | 67.5 ± 1.32 | 7.78 | .014 | 63.24 ± 0.77 | 60.16 ± 0.81 | 5.12 | .006 |
| Scabies | 37.0 ± 1.02 | 60.03 ± 1.69 | −38.36 | <.001 | 41.63 ± 0.98 | 63.81 ± 0.90 | −34.76 | <.001 | 41.06 ± 0.70 | 63.79 ± 0.87 | −35.63 | <.001 |
| Seborrheic dermatitis | 76.88 ± 3.12 | 75.28 ± 1.65 | 2.13 | .652 | 79.5 ± 1.87 | 75.13 ± 1.73 | 5.82 | .086 | 77.94 ± 1.76 | 73.96 ± 1.12 | 5.38 | .056 |
| Seborrheic keratosis | 43.13 ± 1.90 | 62.03 ± 1.87 | −30.47 | <.001 | 63.25 ± 3.0 | 67.56 ± 1.70 | −6.38 | .211 | 69.65 ± 1.59 | 67.82 ± 1.60 | 2.70 | .418 |
| Skin cancer | 55.88 ± 2.64 | 78.38 ± 1.39 | −28.71 | <.001 | 77.63 ± 2.05 | 87.56 ± 0.93 | −11.34 | <.001 | 70.41 ± 1.26 | 74.96 ± 1.20 | −6.07 | .009 |
| Shingles | 66.75 ± 1.93 | 73.69 ± 1.19 | −9.42 | .002 | 79.13 ± 1.29 | 75.91 ± 1.00 | 4.24 | .049 | 91.94 ± 1.09 | 78.21 ± 0.81 | 17.56 | <.001 |
| Squamous cell carcinoma | 29.25 ± 0.70 | 39.41 ± 1.72 | −25.78 | <.001 | 36.5 ± 1.38 | 38.28 ± 0.82 | −4.65 | .267 | 40.76 ± 1.31 | 40.53 ± 1.14 | 0.57 | .892 |
| Stevens Johnson syndrome | 37.5 ± 3.27 | 40.53 ± 2.01 | −7.48 | .430 | 35.38 ± 1.95 | 42.5 ± 2.82 | −16.75 | .038 | 36.35 ± 2.02 | 43.65 ± 1.43 | −16.72 | .003 |
| Syphilis | 23.88 ± 0.12 | 26.34 ± 0.45 | −9.34 | <.001 | 24.75 ± 0.46 | 24.09 ± 0.36 | 2.74 | .259 | 23.71 ± 0.33 | 24.24 ± 0.28 | −2.19 | .221 |
| Tinea | 51.25 ± 1.86 | 64.66 ± 1.18 | −20.74 | <.001 | 66.88 ± 2.13 | 73.69 ± 1.37 | −9.24 | .007 | 66.53 ± 1.37 | 74.12 ± 1.09 | −10.24 | <.001 |
| Varicella | 46.75 ± 1.92 | 61.63 ± 1.54 | −24.14 | <.001 | 52.75 ± 2.21 | 65.75 ± 1.43 | −19.77 | <.001 | 64.59 ± 1.50 | 68.01 ± 1.20 | −5.03 | .075 |
| Vasculitis | 29.5 ± 1.36 | 38.47 ± 0.66 | −23.32 | <.001 | 37.75 ± 0.98 | 40.69 ± 2.04 | −7.23 | .194 | 34.94 ± 0.88 | 38.69 ± 0.53 | −9.69 | <.001 |
| Verruca | 26.63 ± 3.66 | 27.63 ± 1.11 | −3.62 | .794 | 33.88 ± 2.92 | 29.78 ± 1.80 | 13.77 | .232 | 37.18 ± 1.44 | 35.35 ± 1.65 | 5.18 | .405 |
| Vitiligo | 40.13 ± 2.30 | 46.53 ± 1.27 | −13.75 | .015 | 57.0 ± 3.70 | 55.09 ± 1.46 | 3.47 | .631 | 55.82 ± 1.53 | 56.91 ± 1.29 | −1.92 | .586 |
| Urticaria | 54.38 ± 2.62 | 56.09 ± 1.23 | −3.05 | .552 | 56.0 ± 1.34 | 55.13 ± 1.09 | 1.58 | .612 | 55.53 ± 0.93 | 58.44 ± 1.22 | −4.98 | .059 |
| Wart | 68.88 ± 2.65 | 73.06 ± 0.76 | −5.72 | .129 | 83.13 ± 1.44 | 82.78 ± 1.03 | 0.42 | .846 | 76.88 ± 1.56 | 78.81 ± 1.14 | −2.45 | .318 |
| Zoster | 63.25 ± 1.60 | 73.31 ± 1.61 | −13.72 | <.001 | 70.75 ± 3.03 | 76.44 ± 1.91 | −7.44 | .112 | 76.88 ± 1.83 | 76.32 ± 1.25 | 0.73 | .801 |
| Acitretin | 34.5 ± 4.21 | 42.22 ± 2.84 | −18.29 | .128 | 32.5 ± 2.57 | 48.94 ± 2.89 | −33.59 | <.001 | 41.88 ± 2.62 | 45.93 ± 1.87 | −8.82 | .209 |
| Soriatane | 21.86 ± 3.76 | 31.8 ± 2.10 | −31.26 | .021 | 33.0 ± 5.67 | 34.08 ± 2.55 | −3.17 | .863 | 28.81 ± 3.39 | 29.61 ± 2.06 | −2.70 | .840 |
| Dupilumab | 17.63 ± 2.65 | 20.0 ± 1.69 | −11.85 | .449 | 22.63 ± 1.33 | 17.59 ± 1.34 | 28.65 | .008 | 23.0 ± 2.05 | 20.97 ± 1.53 | 9.68 | .428 |
| Dupixent | 62.0 ± 3.00 | 29.75 ± 3.65 | 108.40 | <.001 | 65.25 ± 3.19 | 28.5 ± 3.00 | 128.95 | <.001 | 75.06 ± 2.48 | 37.94 ± 2.70 | 97.84 | <.001 |
| Emollients | 24.63 ± 2.44 | 23.88 ± 1.77 | 3.14 | .804 | 25.43 ± 3.52 | 25.35 ± 3.08 | 0.32 | .987 | 25.12 ± 1.83 | 23.61 ± 1.37 | 6.40 | .510 |
| Isotretinoin | 57 ± 3.24 | 54.97 ± 2.3 | 3.69 | .609 | 57.63 ± 2.34 | 51.38 ± 2.33 | 12.16 | .058 | 57.18 ± 2.36 | 51 ± 1.46 | 12.12 | .026 |
| Accutane + Absorica + Amnesteem + Claravis + Myorisan | 61.63 ± 1.25 | 66.63 ± 0.97 | −7.50 | .002 | 68.63 ± 1.59 | 65.16 ± 1.23 | 5.33 | .085 | 68.65 ± 0.748 | 64.59 ± 0.89 | 6.29 | <.001 |
| Ivermectin | 27.5 ± 10.49 | 5.88 ± 0.12 | 367.69 | .039 | 10.88 ± 0.57 | 5.97 ± 0.13 | 82.24 | <.001 | 12.18 ± 1.06 | 5.49 ± 0.10 | 121.86 | <.001 |
| Stromectol | 28.38 ± 10.36 | 11.31 ± 1.08 | 150.93 | .101 | 14.63 ± 1.39 | 10.81 ± 0.73 | 35.34 | .015 | 12.44 ± 1.51 | 11.13 ± 0.67 | 11.77 | .429 |
| Sklice + Soolantra | 41.63 ± 2.85 | 50.13 ± 2.50 | −16.96 | .025 | 37.88 ± 2.37 | 51.81 ± 1.71 | −26.89 | <.001 | 43.65 ± 2.77 | 50.56 ± 1.30 | −13.67 | .024 |
| Omalizumab | 31.13 ± 4.19 | 34.44 ± 2.24 | −9.61 | .486 | 32.38 ± 3.41 | 32.28 ± 2.13 | 0.31 | .981 | 38.47 ± 3.79 | 34.62 ± 1.72 | 11.12 | .355 |
| Xolair | 57.5 ± 2.46 | 65.44 ± 2.31 | −12.13 | .019 | 57.63 ± 2.0 | 66.0 ± 2.70 | −12.68 | .013 | 67.76 ± 2.32 | 66.62 ± 1.78 | 1.71 | .695 |
| Sunscreen | 31.63 ± 4.44 | 39.66 ± 2.37 | −20.25 | .110 | 75.38 ± 4.29 | 71.13 ± 2.53 | 5.97 | .393 | 37.29 ± 4.09 | 28.5 ± 1.97 | 30.84 | .053 |
| Sun protection | 41.75 ± 4.7 | 48.78 ± 1.91 | −14.41 | .166 | 73.88 ± 3.80 | 73.13 ± 2.12 | 1.03 | .863 | 41.06 ± 4.92 | 37.1 ± 2.19 | 10.67 | .462 |
| Corticosteroid cream | 58.25 ± 6.21 | 45.63 ± 2.49 | 27.66 | .059 | 75.75 ± 4.47 | 48.34 ± 3.07 | 56.70 | <.001 | 60.88 ± 2.12 | 49.94 ± 2.07 | 21.91 | <.001 |
| Temovate + diprolene + dermovate + elocon + taclonex + calcitrene | 44.75 ± 2.51 | 62.41 ± 2.31 | −28.30 | <.001 | 56.0 ± 2.77 | 62.5 ± 2.30 | −10.40 | .071 | 55.29 ± 2.95 | 62.51 ± 1.41 | −11.55 | .027 |
| Tacrolimus ointment | 55.0 ± 3.72 | 38.94 ± 3.08 | 41.24 | .001 | 72.38 ± 3.59 | 47.16 ± 2.77 | 53.48 | <.001 | 75.94 ± 2.95 | 46.93 ± 2.09 | 61.82 | <.001 |
| Protopic | 38.88 ± 4.84 | 52.0 ± 3.08 | −25.23 | .022 | 49.25 ± 2.96 | 52.28 ± 2.57 | −5.80 | .440 | 49.24 ± 3.40 | 55.54 ± 1.71 | −11.34 | .098 |
| Pimecrolimus cream | 43.0 ± 4.71 | 22.38 ± 1.68 | 92.14 | <.001 | 38.13 ± 5.02 | 26.27 ± 2.63 | 45.15 | .036 | 53.47 ± 4.36 | 27.87 ± 1.79 | 91.86 | <.001 |
| Elidel | 45.0 ± 2.78 | 71.84 ± 2.24 | −37.36 | <.001 | 51.63 ± 3.61 | 66.69 ± 2.40 | −22.58 | .001 | 51.35 ± 1.89 | 66.22 ± 1.63 | −22.46 | <.001 |
| Botox | 32.88 ± 2.17 | 51.94 ± 1.36 | −36.70 | <.001 | 58.13 ± 1.87 | 49.16 ± 1.10 | 18.25 | <.001 | 63.41 ± 0.79 | 48.82 ± 0.96 | 29.89 | <.001 |
| Dermapen | 36 ± 2.62 | 59.38 ± 2.47 | −39.37 | <.001 | 50.63 ± 2.44 | 55.31 ± 2.78 | −8.46 | .205 | 45.65 ± 2.76 | 53.84 ± 1.50 | −15.21 | .009 |
| Dermaroller | 55.5 ± 5.84 | 60.34 ± 1.69 | −8.02 | .426 | 64.5 ± 3.73 | 53.47 ± 1.66 | 20.63 | .007 | 51.47 ± 3.46 | 51.34 ± 1.38 | 0.25 | .972 |
| Dermal filler | 36.75 ± 5.64 | 44.69 ± 2.60 | −17.77 | .201 | 53.75 ± 6.86 | 46.78 ± 2.68 | 14.90 | .344 | 64.35 ± 4.50 | 44.18 ± 1.75 | 45.65 | <.001 |
| Fractional Laser | 16.13 ± 2.03 | 39.84 ± 2.57 | −59.51 | <.001 | 31.5 ± 3.47 | 31.97 ± 1.33 | −1.47 | .900 | 31.35 ± 1.81 | 35.57 ± 1.62 | −11.86 | .082 |
| Laser epilation | 30.88 ± 4.01 | 38.52 ± 2.73 | −19.83 | .115 | 32.5 ± 2.98 | 35.56 ± 2.64 | −8.61 | .442 | 36.36 ± 4.03 | 42.25 ± 2.52 | −13.94 | .215 |
| Peeling | 66 ± 4.19 | 58.56 ± 0.88 | 12.70 | .083 | 89.38 ± 2.66 | 72 ± 1.56 | 24.14 | <.001 | 73.06 ± 2.80 | 64.46 ± 1.46 | 13.34 | .006 |
| Patch testing | 52.25 ± 6.97 | 46.69 ± 3.43 | 11.91 | .474 | 52.75 ± 6.27 | 42.22 ± 2.31 | 24.94 | .115 | 62.41 ± 4.40 | 44.1 ± 1.83 | 41.52 | <.001 |
| Skin Prick test | 25.17 ± 5.72 | 32.83 ± 3.25 | −23.33 | .244 | 30.38 ± 6.26 | 27.3 ± 2.30 | 11.28 | .644 | 29.38 ± 2.49 | 23.81 ± 1.20 | 23.39 | .044 |
| Skin allergy test | 31.13 ± 1.95 | 51.78 ± 2.88 | −39.88 | <.001 | 43.25 ± 3.05 | 52.38 ± 2.7 | −17.43 | .025 | 48 ± 3.00 | 46.41 ± 1.67 | 3.43 | .644 |
| Phototherapy | 61.13 ± 5.03 | 58.22 ± 1.81 | 5.0 | .587 | 52.5 ± 3.55 | 51.81 ± 1.26 | 1.33 | .855 | 57.88 ± 3.22 | 53.46 ± 1.35 | 8.27 | .204 |
| PRP | 51.13 ± 1.60 | 68.97 ± 2.13 | −25.87 | <.001 | 69.63 ± 1.89 | 66.72 ± 1.82 | 4.36 | .268 | 80.82 ± 1.40 | 68.81 ± 1.44 | 17.45 | <.001 |
| Mesotherapy | 25 ± 2.40 | 50.5 ± 2.39 | −50.5 | <.001 | 50.88 ± 3.36 | 48.84 ± 2.84 | 4.18 | .645 | 59.06 ± 3.92 | 46.1 ± 1.55 | 28.11 | .002 |
| Skin | 84.38 ± 3.38 | 79.72 ± 0.72 | 5.85 | .178 | 96.25 ± 0.93 | 83.47 ± 0.95 | 15.31 | <.001 | 88.59 ± 1.23 | 79.03 ± 0.88 | 12.10 | <.001 |
| Skin care | 83.63 ± 5.17 | 70.63 ± 0.84 | 18.41 | .013 | 90.88 ± 2.06 | 68.31 ± 1.24 | 33.04 | <.001 | 79.71 ± 1.30 | 66.32 ± 0.78 | 20.19 | <.001 |
| Dermatologist | 43 ± 2.34 | 79.03 ± 0.94 | −45.59 | <.001 | 75.88 ± 2.91 | 83.25 ± 1.04 | −8.85 | .017 | 80.35 ± 0.68 | 80.94 ± 1.10 | −0.73 | .649 |
Notes: Plus‐minus values are means ± standard error (generalized estimating equations).
Abbreviation: PRP, platelet rich plasma.