Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jan 28;13(4):e1700. doi: 10.1002/wnan.1700

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 Wiley Periodicals LLC.

This article is being made freely available through PubMed Central as part of the COVID-19 public health emergency response. It can be used for unrestricted research re-use and analysis in any form or by any means with acknowledgement of the original source, for the duration of the public health emergency.

PMC Copyright notice

A “driver switchover” mechanism of influenza virus transport from microfilaments to microtubules (L.‐J. Zhang, Xia, et al., 2018). The switch between microfilament (MF)‐ and microtubule (MT)‐based retrograde motor proteins, myosin VI (myoVI) and dynein, took over the seamless transport of viruses from MFs to MTs during their infection. After entering the virus through endocytosis, both types of motor proteins are attached to the virus‐carrying vesicles. MyoVI used dynein to drive the virus on the MF on the virus‐carrying vesicle hitchhiking. After the role exchanges at the actin‐microtubule intersections, dynein moves the virus along the MTs toward the perinuclear region