Table. Patient Data.
| Patient No. | MOGa | Eye(s) | Onset | Symptoms | Optic disc edema | White matter lesions on masked MRI review | Lesions | Enhancement | logMAR (Snellen equivalent) | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subcortical white matter | Cortical | Deep gray hyper | Optic nerve | Perineural | Sheath | Baseline | 6 mo | |||||||
| 1 | Positive | Both | Bilateral simultaneous | Headache | Both | Yes | Absent | 1 or 2 | Absent | Both | NA | Both | OS: 1.70 (<20/800); OD: 0.16 (20/30) | NA |
| 2 | Positive | Right | Bilateral simultaneous | Difficulty with coordination, headache | Right | No | Absent | None | Absent | Left | NA | Left | OD: 1.70 (<20/800) | OD: 0.04 (20/20) |
| 3 | Positive | Left | Unilateral | Headache | Left | Yes | Absent | None | Absent | Left | Left | Left | OS: 0 (20/20) | OS: −0.10 (20/15) |
| 4 | Positive | Both | Bilateral simultaneous | NA | NA | Yes | Absent | None | Absent | Both | NA | Both | OS: 1.70 (<20/800); OD: 1.70 (<20/800) | OS: 0.60 (20/80; OD: 0.60 (20/80) |
| 5 | Positive | Right | Unilateral | Headache | NA | Yes | Absent | None | Present | Right | NA | NA | OD: 0.70 (20/100) | OD: 0 (20/20) |
| 6 | Positive | Left | Unilateral | NA | Left | Yes | Absent | ≥3 | Absent | Left | Left | Left | OS: 1.70 (<20/800) | OS: 0.30 (20/40) |
| 7 | Positive | Both | Bilateral simultaneous | NA | Both | No | Absent | None | Absent | Both | NA | Both | OS: 1.70 (<20/800); OD: 0.20 (20/30) | OS: 0.10 (20/25); OD: −0.10 (20/15) |
| 8 | Negative | Right | Unilateral | Focal weakness, headache | NA | Yes | Absent | ≥3 | NA | NA | NA | NA | OD: 0.10 (20/25) | OD: −0.16 (20/15) |
| 9 | Negative | Right, then left | Bilateral sequential | NA | Right | No | Absent | None | Absent | Both | NA | NA | OD: 0.70 (20/100) | OD: 1.40 (20/500) |
| 10 | Negative | Left | Unilateral | NA | NA | No | Absent | None | Absent | NA | NA | NA | OS: −0.06 (20/20) | OS: 0 (20/20) |
| 11 | Negative | Right | Unilateral | Headache | Right | No | Absent | None | Absent | Right | NA | Both | OD: 0.20 (20/30) | OD: 0 (20/20) |
| 12 | Negative | Both | Bilateral simultaneous | NA | Both | Yes | Present | None | Absent | Both | NA | Both | OS: 0.10 (20/25); OD: 0.50 (20/60) | OS: 0 (20/20); OD: 0 (20/20) |
| 13 | Negative | Both | Bilateral simultaneous | NA | Both | No | Absent | None | Absent | Both | Both | Left | OS: 1.30 (20/400); OD: 0.80 (20/125) | NA |
Abbreviations: Deep gray hyper, deep gray matter hyperintense lesions; MOG, myelin oligodendrocyte glycoprotein; MRI, magnetic resonance imaging; NA, not applicable.
a
MOG was determined by the Mayo Clinic.